|
 Game Title | Publisher | Genre | Platform |
| Silmar | | Role-Playing (RPG) | DOS, Linux, Macintosh, Windows |
| Silver Surfer | Arcadia Systems, Inc. | Action | NES |
| SimCity | Infogrames Europe SA, Brøderbund Software, Inc., Erbe Software, S.A., Fujitsu Interactive, Imagineer Co., Ltd., Krisalis Software Ltd., Maxis Software Inc., Nintendo Co., Ltd., Nintendo of America Inc., Nintendo of Europe GmbH, Superior Software Ltd., Superior Interactive | Simulation | Acorn 32-bit, Amiga, Amstrad CPC, Atari ST, BBC Micro, CDTV, Commodore 64, DOS, Electron, FM Towns, Macintosh, PC-98, Sharp X68000, SNES, Wii, Windows 3.x, ZX Spectrum |
| SimCity Graphics Set 1: Ancient Cities | Infogrames Europe SA, Maxis Software Inc. | Simulation | Amiga, DOS |
| SimEarth: The Living Planet | Ocean Software Ltd., Electronic Arts, Inc., FCI, Hudson Entertainment, Inc., Hudson Soft Company, Ltd., Imagineer Co., Ltd., Maxis Software Inc., Mindscape International Ltd., SEGA Enterprises Ltd. | Educational, Simulation | Amiga, DOS, FM Towns, Macintosh, PC-98, SEGA CD, Sharp X68000, SNES, TurboGrafx CD, Wii, Windows 3.x |
| Simulcra | MicroStyle | Action | Amiga, Atari ST |
| Sinbad and the Throne of the Falcon | Cinemaware Corporation, Mindscape, Inc., Mirrorsoft Ltd. | Action, Strategy | Amiga, Apple IIgs, Atari ST, Commodore 64, DOS |
| Sinclair User DoubleHits 5 | ECC Publications Ltd. | | ZX Spectrum |
| Sinclair User Six of the Best 1 | ECC Publications Ltd. | | ZX Spectrum |
| Sindibad: Chitei no Daimakyū | IGS Corp. | Role-Playing (RPG) | TurboGrafx-16 |
| Sinistron | IGS, Inc., Information Global Service | Action | TurboGrafx-16 |
| Sirwood | Opera Soft S.A. | Action | Amstrad CPC, DOS, MSX, ZX Spectrum |
| Sito Pons 500cc Grand Prix | Zigurat | Racing / Driving, Sports | Amstrad CPC, DOS, MSX, ZX Spectrum |
| Skate or Die 2: The Search for Double Trouble | Electronic Arts, Inc. | Action, Sports | NES |
| Skidz | Gremlin Graphics Software Ltd. | Action, Racing / Driving | Amiga, Atari ST |
| Ski or Die | Electronic Arts, Inc., Electronic Arts Ltd., Ultra Games | Sports | Amiga, Commodore 64, DOS, NES |
| Skull & Crossbones | Tengen Inc. | Action | NES |
| SkyChase | Brøderbund Software, Inc., Image Works, Mirror Image | Action, Simulation | Amiga, Atari ST, DOS |
| Slap Shot | SEGA of America, Inc. | Sports | SEGA Master System |
| Sly Spy: Secret Agent | Ocean Software Ltd. | Action, Racing / Driving | Amiga, Amstrad CPC, Atari ST, Commodore 64, ZX Spectrum |
| Snake Rattle N Roll | Nintendo of America Inc., SEGA Enterprises Ltd. | Action | Genesis, NES |
| Snake's Revenge | Ultra Software Corporation | Action | NES |
| Snoopy's Magic Show | Kemco/Seika, Kotobuki System Co., Ltd. | Strategy | Game Boy |
| Snoopy: The Cool Computer Game | Edge, The | Adventure | Amiga, Amstrad CPC, Atari ST, CDTV, DOS, ZX Spectrum |
| Snow Strike | Epyx, Inc., U.S. Gold Ltd. | Action, Simulation | Amiga, Amstrad CPC, Atari ST, Commodore 64, DOS, ZX Spectrum |
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