Buzz!: Master Quiz is the first release of the Buzz! quiz series on the PSP. Like with the previous console games in the series, it is a party game that features over 3,000 questions and it can be played in solo or multiplayer modes. Multiplayer games are supported for a single PSP and a single copy of the game (Pass Around), a single copy of the game and multiple devices (Game Sharing), or multiple PSPs and multiple copies (regular wireless mode).

In the Pass Around mode six rounds can be played: Picture This, Rollover, Short Fuse, Weak Spot, Virus and Snapshot - each with different gameplay and rules. There is also a Quiz Host mode where one player becomes the master of ceremony and leads the quiz. That way he can show a picture on the PSP to the different players and add/deduct points for the answers.

The solo mode has fifteen challenges to beat. Each challenge gives the player a bronze, silver or gold medal. It is also possible to unlock trophies for things like numbers of right answers in a row or fastest time for an answer.

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