Qix indirectly lead to the name of Dr. Zoidberg, a character from the animated Futurama series. David X. Cohen, the creator of the series, created Zoid, a Qix clone, and eventually used that name for the character.
Mario and Luigi make a cameo appearance in the Game Boy version of Qix.
With a VGA card or some EGA cards, a non-standard 16 color palette was used. If this mode was supported the program autodected it, otherwise the default EGA palette was used. Likewise in 4 color mode, if an MCGA or VGA card was detected a non-standard 4 color palette was used.