William Shatner's TekWar Trivia (DOS)
Though the game was a tie-in for the television series the only actor crossover is William Shatner, playing his character Walter Bascom. All the other actors aren't present and the Tek Lords themselves are represented by entirely different actors. There is even a small snippet taken from the television show added to the game. A scene where Walter Bascom describes the drug Tek and some of its effects was used in one of the episodes that ran early in the series.
This game is based on the Tek War books by William Shatner. The Tek War franchise also contains a TV series and a couple of made-for-tv movies.