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In this Tetris-style game, you play as Dr. Mario, who must drop differently coloured pills onto viruses to remove them from the bottle. Each pill is split into two, with each side being of one of three different colours, red, blue or yellow. Align three pills of the same colour to a virus of the corresponding colour (or any combination of pills and viruses totaling four or more) and it will be removed from the bottle, along with the aligned pills. The level is cleared when there are no viruses left, and the game is over when the pills reach the top and Dr. Mario can't drop any more pills.

Included in the game is the normal mode, a time trial, and a two player battle mode to see who can remove the most viruses.


Dr. Mario Arcade About to remove some pills
Dr. Mario SNES Playing a 2 player game.
Dr. Mario SNES Starting the level 0
Dr. Mario NES You can get further than 20 lvl but there won't be any changes

Promo Images

Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot

Alternate Titles

  • "Virus" -- Working title
  • "ドクターマリオ" -- Japanese spelling

Part of the Following Groups

User Reviews

Tetris leveled up! NES Pixelspeech (949)
Best mindless entertainment game since Tetris. NES Multimedia Mike (19083)
A classic puzzle game which still remains enjoyable today NES Jon Collins (28)
Play "Tetris" with Mario. Game Boy Michael B (341)
Everybody (especially Tetris fans) will find themselves addicted to this game in minutes. Game Boy pocketgamer2000 (22)

Critic Reviews

Nintendojo NES 2003 10 out of 10 100
NES Archives NES Mar 22, 2008 A- 91
NES Times NES Feb 15, 2008 9 out of 10 90
Video Games Game Boy Jun, 1991 83 out of 100 83
Nintendojo Game Boy Advance 2004 7.7 out of 10 77
Total!! UK Magazine Game Boy Jan, 1992 64 out of 100 64 Wii U Feb 23, 2014 6 out of 10 60
Electronic Gaming Monthly (EGM) Game Boy Nov, 1990 23 out of 40 58
FNintendo Wii U Feb 28, 2014 4 out of 10 40
Cheat Code Central Game Boy Advance 2004 2 out of 5 40


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1001 Video Games

Dr. Mario appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.


  • Game Informer
    • August 2001 (Issue #100) - #76 in the "Top 100 Games of All Time" poll

Related Web Sites

Contributed to by Michael Cassidy (17997), Kartanym (10697) and gamewarrior (5060)