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This cartridge has two games, Dr. Mario and Puzzle League.

Dr. Mario is a puzzle game where you move bi-color pills into formation to wipe out viruses. The game features several gameplay modes: Classic, Flash, versus CPU, and Vertical. You can play the Flash and versus CPU modes via wireless link with another player.

Puzzle League is a translated version of the Panel de Pon GBA game, which was available as a GBA download in the Japanese Nintendo Puzzle Collection for GameCube. American players may recognize this game as Tetris Attack or Pokémon Puzzle League. A pile of colored tiles moves upwards on the screen as the player attempts to rearrange them to eliminate groups of three or more like types. The in-game characters who appear throughout the game to challenge or encourage the player are generic cute characters; none of Nintendo's famous mascots make an appearance. You can play in one of six modes: Marathon, versus CPU, Timed, Line, Garbage, and Puzzle.


Dr. Mario & Puzzle League Game Boy Advance Panel de Pon Japanese title screen
Dr. Mario & Puzzle League Game Boy Advance Title screen.
Dr. Mario & Puzzle League Game Boy Advance Dr. Mario title screen.
Dr. Mario & Puzzle League Game Boy Advance Title screen (Japanese version)

Promo Images

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Alternate Titles

  • "玛丽医生" -- Chinese spelling (simplified)
  • "Dr. Mario & Panel de Pon" -- Japanese title
  • "ドクターマリオ&パネルでポン" -- Japanese spelling

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User Reviews

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Critic Reviews

Game Informer Magazine Jan, 2006 9 out of 10 90 Nov 17, 2005 86 out of 100 86
GameSpot Dec 12, 2005 8 out of 10 80 Dec 16, 2005 78.5 out of 100 78
1UP Dec 01, 2005 7.5 out of 10 75 (UK) May 12, 2005 7 out of 10 70
GamePro (US) Dec 05, 2005 3.5 out of 5 70
GamerDad Mar 09, 2006 3.5 Stars3.5 Stars3.5 Stars3.5 Stars3.5 Stars 70
GameSpy Dec 05, 2005 3.5 out of 5 70
Video Game Generation Feb 28, 2006 6 out of 10 60


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  • GameSpy
    • 2005 – GBA Puzzle Game of the Year

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Lisa Shock (147) added Dr. Mario & Puzzle League (Game Boy Advance) on Feb 20, 2006