DevelopmentDeveloper Arush originally planned to do a remake of the original Duke Nukem platform game. In the game's folders there still is a soundfile called "proton", where Duke talks about the enemy he fights against. Proton was his enemy in the original Duke Nukem game from 1991. However, Arush then made up their own story with Morphix being the enemy.
EditorFollowing the tradition started in Duke Nukem 3D, the game includes a complete level editor hidden in the CD's folders.
ExtrasThe initial release included a limited edition collectors keychain. The silver colored metallic keychain is circular in design. One side says "Duke Nukem Manhattan Project" and shows the Statue of Liberty with Duke Nukem's signature radioactive (Nuke) symbol behind it. The other side has "NYC" in big letters and says "Good for one fare - Transit authority".
- In the first stage, there's an outdoor to the "Rats" play, a reference to Broadway's Cats.
- In the second stage, if you pick up a public phone you'll hear a woman's voice saying something like "I know you're searching something Duke, and I know how you feel. Follow the White Rabbit", a reference to The Matrix movie.
- Latter in the second stage, Duke must avoid some cars crossing a street. As he does it a couple of times, he says "what am I, a frog?", a reference to Frogger, the game.
ReleaseAccording to some reports, some retailers were initially not intending to stock this game claiming that it would not sell very well due to it being a budget release.
Information also contributed by chirinea, Daniel Saner and Zovni