As with all games in the Bust-a-Move puzzle series, you must fire colored bubbles into a puzzle of other colored bubbles in order to create patterns of like colors. Once the patterns reach a certain size, they disappear revealing more bubbles behind them. The goal is to remove all bubbles from the screen and progress to the next level. As time progresses in the level, more bubbles appear from the top of the screen and the whole puzzle moves lower, eventually reaching the bottom and ending the game if you are unsuccessful in creating enough patterns.

The minimum number of bubbles that are required to make a the bunch disappear is three, however if there are more of the same color connected they will all disappear. Different levels will have special bubbles that follow different rules, as well as different blocks that behave differently to add some variety to the gameplay.

Gameplay modes include Classic and Normal, as well as Player vs. CPU. Multiplayer is also available to battle against another human opponent. Classic mode will provide you with puzzles of a simpler design, many of which were found in earlier Bust-a-Move titles or slight variations of them. Normal mode introduces special bubbles and blocks for more dynamic gameplay.

[edit description]