The Legend of Zelda: Twilight Princess
Looks that way - there's a trivia note about it:
"The Wii and GameCube versions of this game have the world map and everything in it mirrored. This is to make the game work for the right handed Link of the Wii and the left handed Link of the GameCube. So everything stays the same relative to him." Contributed by Keeper Garrett (528) on Jan 07, 2007.
I didn't think it that easy to just flip it programming wise considering a lot of things can't be simply just flipped like symbols and text + I don't think too many game engines have a flip button all the graphics have to be done individually. Could be wrong though, does anyone in this field know, interested to find out.