Game PackageThe game came with extremely realistic materials. It included an internal memo and pathology course, both typed with a dactylo, photocopied and then stapled by hand. And if you looked under the bottom cardboard in the box, you could find a real pair of surgical gloves and a surgery mask!
References to the GameAt the end of the fourth episode in the anime about otaku lifestyle Genshiken (1st season, 2004), when Saki asks her boyfriend Kousaka "What was your first time like?", he misunderstands the question and, being an otaku, starts naming the first anime series and games he tried. Among the games he first played, Life & Death is mentioned, alongside Ultima (without specifying which one) and The Manhole. Regarding Life & Death Kousaka adds: "I don't even know how many people I killed in that". Usually however, both in the anime and the original manga, all the titles of popular entertainment products are altered to avoid copyright problems (e.g. The Chanp of Fighters 95 instead of The King of Fighters '95, Berserker instead of the popular manga Berserk). Other notable exceptions to this are the Puyo Puyo and Guilty Gear game series.
SimulationThe simulation is actually quite strict: Deviate a hair too much from the proper incision technique, and you'll find your license revoked or your physician alter-ego kicked back to medical school. This was done intentionally to emphasize the importance of the topic.
SoundThis game had a few digital sounds that came out of the PC Speaker, which was quite uncommon back then, and led to compatibility problems on certain machines.
Contributed by Olivier Masse (421) on May 06, 1999. [revised by : CalaisianMindthief (3058) and Jo ST (6437)]. -- edit trivia