In the action sequences you control a single ghostbuster who can fire his slime weapon and jump. In driving sequences you move the Ecto-1A around the screen and your controls are also a slime gun and jumping. Additionally you must find speed arrows on the ground to jump over huge chasms. Finally, while controlling the Statue of Liberty you may fire her torch straight up into the air (find a power-up torch to shoot diagonally) or let loose the tablet that she carries to destroy all enemies on the screen.
Find 20 "Ghostbusters 2" symbols in any of these levels to obtain an extra life.