missing cover art
It has been suggested over on Wikipedia that the game's unusual title may well be a reference to the notorious cult movie (much-beloved of MST3K) Manos: The Hands of Fate (1966).
After Zanthia meets the Hand on the rainbow bridge, the costume she changes into is the same one worn by Sylvester Stallone in "Rambo".
Legend of Kyrandia 2: Hand of Fate was also released on CDROM. This version had full speech throughout the game, although the game was similar to the earlier disk release.