One of the trivia items we have says that RE4 was, at one point, going to be set in Japan. To the best of my knowledge no version of RE4 was ever set in Japan. The first version (back when it was still RE3) was set on a boat, and every version after that was set somewhere in Europe.
Another one says that the Spanish in the game is a poor imitation of native accent Spanish, but I remember a friend of mine, who lived in Spain for a few years, being impressed by how accurate RE4's rural Spanish sound was. Actually I suppose he could have been sarcastic about that. It's difficult to tell some times.