1001 Video GamesResident Evil 5 appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.
Jill ValentineIn what may be a subtle nod to Namco, Jill Valentine's appearance at a certain point in the game resembles Nina Williams from Namco's Tekken fighting game series, specifically Tekken 5.
- 2009 – #4 Best Game of the Year (Readers' Vote)
- 2009 – Best Action Game of the Year
- 2009 – #3 Best Graphics of the Year
- 2009 – #3 Best Viral Trailer of the Year
- Gamespot (Editor Choice Awards)
- 2009 - Character Most Likely to Fail a Performance Enhancing Drug Test (for the character Chris Redfield)
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Big John WV
- 2009 - PC Award for Visual Excellence (Game of the Year Editor's Awards)