The song Suffer Like G Did is a nod to The House of the Dead 2, in which one of the bosses proclaims: "Turn back now or suffer like G did!"
It received three awards in GameShark's Game of the Year Awards 2009:
- Wii Game of the Year
- Best Soundtrack
- Most Underhyped Game
The game received the award for Funniest Game in Gamespot's 2009 Editor Choice Awards.
Only a month after its release, The House of the Dead: Overkill received a Guinness World Record for being the most profane game ever released, featuring 189 uses of "the f word". When hearing about the award, game writer Jonathan Burroughs went to say the following:
"It is a dubious honor to receive such an accolade working in an industry where so often the fruits of your labours are derided and dismissed for being puerile or irresponsible, but in the case of The House of the Dead: Overkill a little puerility was the order of business. Parodying the profane excess of grindhouse cinema was Headstrong Games’ objective and I am flattered that this record acknowledges that we not only rose to that challenge, but entirely exceeded it."