When loading a city, one of the random things the loader says is "Pixelizing Nude Patch." This is a reference to nude patches for The Sims, some which even make the nudity more realistic.
Most of the buildings are named after the developers of the game. (refer to the Credits page)
Contrary to popular belief, the graphical perspective of SimCity 4 is actually trimetric rather than isometric, meaning none of the three visible sides of an object are equally viewable. SimCity 2000 and 3000 had dimetric perspectives, meaning the sides are equally visible, but the top is less visible. There has never been an isometric SimCity.
A bonus Transportation disc comes with the game if you ordered the game at Electronics Boutique.
The game was supposed to be released on January 14th, 2003. However, it was shipped to retailers before the release date, and they put it on shelves before the release date. EA got angry at the retailers, but let it go and dropped the release date.