Four of the playable characters in the game, Sadamitsu, Tsuna, Kintoki, and Suetake, are based on actual people associated with the real life Raikoh, although how much is actually true about any of them is difficult to tell due to the wealth of folk tales written about the group. Sadamitsu is traditionally depicted as male, but starting in the 20th century appears to be depicted more and more as a female.
Seimei is also based on a real-life person and folk character: Abe no Seimei. The real Seimei was also male. A fictional female Seimei also appears in FromSoftware's Kuon.