Knuckle Heads is 2D weapon-based fighting game. The player chooses one from six characters and fights against others. Each character has own weapons to use like tonfas, axes, kusarigama or quarterstaff. Game hasn't any bosses. Knuckle Heads has multi-player mode to 4 players simultaneously - and then uses 2 planes, like Fatal Fury. Game uses three buttons: High Attack, Low Attack, and Jump.