Asphyxia is a visual novel romance that focuses on the protagonist Samantha, who is very depressed. The depression is getting worse and Samatha leans upon her best friend Lillian. Even though she has always seen Lillian as her best friend their relationship falls apart. Three months later the two girls are forced to be together again on their geography field trip to the Lake District and Samantha wants to make things right. But more feelings are at play here, as Samantha may feel more for Lillian than just friendship. The game features several choices that can lead to multiple endings. The game only contains girl characters and thus features Yuri.