Much like the DS version, Cartoon Network Racing is a kart racer along the lines of Mario Kart, where players race one of several characters from various Cartoon Network shows (Johnny Bravo, Dexter's Lab, Cow and Chicken, The Powerpuff Girls, I Am Weasel and Courage the Cowardly Dog) and use weapons and power ups to beat opponents.
The major difference here is that the game includes dual riders like Mario Kart Double Dash - one to drive, and one to utilize various weapons. The karts have different stats, and so do the co-drivers, who have various "toon powers" - such as shields, speed boosts, damage output and flying capabilities.
The game includes various modes typical of racing games, such as tournament mode, battle mode and elimination races, with tournament unlocking new drivers and courses, and bonuses such as full episodes from the various shows. The game allows for 2 player multiplayer.