Atlantis: The Lost Empire is a 3D action game with puzzle-solving elements, based on Disney's film of the same name. The player can take control of one of six different characters (Milo Thatch, Gaetan Molière, Vincenzo Santorini, Audrey Ramirez, Wilhelmina Packard and Kidagakash), trying to reach the lost city of Atlantis and save it from destruction.
Each character possesses his or her own unique abilities and the player can switch between them using radio's found around the levels. The gameplay is reminiscent of Tomb Raider games, involving combat and predominantly physical and environmental puzzles. There is also a section where the player controls a submarine and has to take on the leviathan guarding the entry to Atlantis.