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In this Tetris-style game, you play as Dr. Mario, who must drop differently coloured pills onto viruses to remove them from the bottle. Each pill is split into two, with each side being of one of three different colours, red, blue or yellow. Align three pills of the same colour to a virus of the corresponding colour (or any combination of pills and viruses totaling four or more) and it will be removed from the bottle, along with the aligned pills. The level is cleared when there are no viruses left, and the game is over when the pills reach the top and Dr. Mario can't drop any more pills.

Included in the game is the normal mode, a time trial, and a two player battle mode to see who can remove the most viruses.


Dr. Mario Arcade Pills are stacking up
Dr. Mario Game Boy Advance Title Screen
Dr. Mario SNES Title screen / Main menu.
Dr. Mario Game Boy Gameplay on Super Game Boy.

Promo Images

Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot


Alternate Titles

  • "Virus" -- Working title
  • "ドクターマリオ" -- Japanese spelling
  • "닥터 마리오" -- Korean spelling (Hangul)

Part of the Following Groups

User Reviews

Tetris leveled up! NES Asinine (1006)
Best mindless entertainment game since Tetris. NES Multimedia Mike (20631)
A classic puzzle game which still remains enjoyable today NES Jon Collins (28)
Play "Tetris" with Mario. Game Boy Michael B (356)
Everybody (especially Tetris fans) will find themselves addicted to this game in minutes. Game Boy pocketgamer2000 (22)

Critic Reviews

NES Times NES Feb 15, 2008 9 out of 10 90
1UP! NES Dec 06, 2001 90 out of 100 90
Nintendo Magasinet (Sweden) NES Jun, 1991 4.5 out of 5 90
Armchair Empire, The Game Boy Advance Jan 09, 2005 8.6 out of 10 86
Raze Game Boy Dec, 1990 81 out of 100 81
neXGam NES 2002 6.8 out of 10 68
Play Time NES Jun, 1991 65 out of 100 65
Game Freaks 365 Game Boy Advance 2004 6 out of 10 60
FNintendo Wii U Feb 28, 2014 4 out of 10 40
Cheat Code Central Game Boy Advance 2004 2 out of 5 40


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1001 Video Games

Dr. Mario appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.


  • Game Informer
    • August 2001 (Issue #100) - #76 in the "Top 100 Games of All Time" poll

Related Web Sites

Contributed to by Michael Cassidy (21142), Kam1Kaz3NL77 (353553), Kartanym (12728) and gamewarrior (5048)