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In this Tetris-style game, you play as Dr. Mario, who must drop differently coloured pills onto viruses to remove them from the bottle. Each pill is split into two, with each side being of one of three different colours, red, blue or yellow. Align three pills of the same colour to a virus of the corresponding colour (or any combination of pills and viruses totaling four or more) and it will be removed from the bottle, along with the aligned pills. The level is cleared when there are no viruses left, and the game is over when the pills reach the top and Dr. Mario can't drop any more pills.

Included in the game is the normal mode, a time trial, and a two player battle mode to see who can remove the most viruses.


Dr. Mario SNES If you want to play Vs. Com, select a difficulty level.
Dr. Mario NES Starting a one player game
Dr. Mario SNES The pills reached the top of the bottle. Game over.
Dr. Mario Game Boy Title screen on Game Boy Color. The game is internally detected and a (not user selectable) palette gets assigned.

Promo Images

Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot

Alternate Titles

  • "Virus" -- Working title
  • "ドクターマリオ" -- Japanese spelling

Part of the Following Groups

User Reviews

Tetris leveled up! NES Pixelspeech (1006)
Best mindless entertainment game since Tetris. NES Multimedia Mike (19808)
A classic puzzle game which still remains enjoyable today NES Jon Collins (28)
Play "Tetris" with Mario. Game Boy Michael B (358)
Everybody (especially Tetris fans) will find themselves addicted to this game in minutes. Game Boy pocketgamer2000 (22)

Critic Reviews

Consoles Plus Game Boy Sep, 1991 95 out of 100 95
Ultimate Nintendo: Guide to the NES Library NES 2016 4.5 Stars4.5 Stars4.5 Stars4.5 Stars4.5 Stars 90
Mean Machines Game Boy Feb, 1991 87 out of 100 87
Raze Game Boy Dec, 1990 81 out of 100 81 SNES Apr, 2006 8 out of 10 80
Nintendojo Game Boy Advance 2004 7.7 out of 10 77
Play Time NES Jun, 1991 65 out of 100 65
Total!! UK Magazine Game Boy Jan, 1992 64 out of 100 64 Wii U Feb 23, 2014 6 out of 10 60
JeuxActu Game Boy Advance Jan 31, 2005 10 out of 20 50


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1001 Video Games

Dr. Mario appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.


  • Game Informer
    • August 2001 (Issue #100) - #76 in the "Top 100 Games of All Time" poll

Related Web Sites

Contributed to by Michael Cassidy (20713), Kartanym (12825) and gamewarrior (5111)