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In this Tetris-style game, you play as Dr. Mario, who must drop differently coloured pills onto viruses to remove them from the bottle. Each pill is split into two, with each side being of one of three different colours, red, blue or yellow. Align three pills of the same colour to a virus of the corresponding colour (or any combination of pills and viruses totaling four or more) and it will be removed from the bottle, along with the aligned pills. The level is cleared when there are no viruses left, and the game is over when the pills reach the top and Dr. Mario can't drop any more pills.

Included in the game is the normal mode, a time trial, and a two player battle mode to see who can remove the most viruses.


Dr. Mario SNES I eliminated the red virus.
Dr. Mario Arcade About to remove some pills
Dr. Mario SNES Playing a 2 player game.
Dr. Mario NES Depending on the level and speed setting a different creature will fly by

Promo Images

Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot


Alternate Titles

  • "Virus" -- Working title
  • "ドクターマリオ" -- Japanese spelling
  • "닥터 마리오" -- Korean spelling

Part of the Following Groups

User Reviews

Tetris leveled up! NES Asinine (1006)
Best mindless entertainment game since Tetris. NES Multimedia Mike (20636)
A classic puzzle game which still remains enjoyable today NES Jon Collins (28)
Play "Tetris" with Mario. Game Boy Michael B (350)
Everybody (especially Tetris fans) will find themselves addicted to this game in minutes. Game Boy pocketgamer2000 (22)

Critic Reviews

Hey Poor Player Game Boy Jan 15, 2013 5 Stars5 Stars5 Stars5 Stars5 Stars 100
NES Archives NES Mar 22, 2008 A- 91
Armchair Empire, The Game Boy Advance Jan 09, 2005 8.6 out of 10 86
Megablast Game Boy 1992 82 out of 100 82
GameSpot Game Boy Advance Nov 02, 2004 7.4 out of 10 74
IGN Game Boy Advance Oct 26, 2004 7 out of 10 70
neXGam NES 2002 6.8 out of 10 68
The Video Game Critic NES Aug 21, 2010 B- 67
Total!! UK Magazine Game Boy Jan, 1992 64 out of 100 64 Game Boy Advance Jan 12, 2005 8 out of 20 40


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1001 Video Games

Dr. Mario appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.


  • Game Informer
    • August 2001 (Issue #100) - #76 in the "Top 100 Games of All Time" poll

Related Web Sites

Contributed to by Michael Cassidy (21110), Kam1Kaz3NL77 (457009), Kartanym (12706) and gamewarrior (5042)
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