Centipede for the Game.Com is an updated version of the classic arcade game. Besides an adaptation of the original game, the cartridge also includes an updated mode with higher resolution graphics and increased difficulty. Up to four players can play taking turns.
Gameplay is unchanged from the original. The player controls a figure at the bottom of the screen that has to shoot at insects, including spiders, fleas and scorpions, and most importantly, a centipede that moves horizontally and moves closer towards the bottom of the screen when hitting an obstacle. When hit by a shot, the centipede splits into two separate sections.
Game options include selectable difficulty, number of lives and movement speed. The start level can also be chosen. There is also an option to flip the screen so the game can be played with d-pad and buttons reversed from the standard.