Join our Discord to chat with fellow friendly gamers and our knowledgeable contributors!

Not an American user?


In this Tetris-style game, you play as Dr. Mario, who must drop differently coloured pills onto viruses to remove them from the bottle. Each pill is split into two, with each side being of one of three different colours, red, blue or yellow. Align three pills of the same colour to a virus of the corresponding colour (or any combination of pills and viruses totaling four or more) and it will be removed from the bottle, along with the aligned pills. The level is cleared when there are no viruses left, and the game is over when the pills reach the top and Dr. Mario can't drop any more pills.

Included in the game is the normal mode, a time trial, and a two player battle mode to see who can remove the most viruses.


Dr. Mario Game Boy I guess it's loosing again.
Dr. Mario Game Boy Gameplay on Super Game Boy.
Dr. Mario Game Boy Ouch, again?
Dr. Mario Game Boy Title screen on Game Boy Color. The game is internally detected and a (not user selectable) palette gets assigned.

Promo Images

Dr. Mario Magazine Advertisement
Dr. Mario Screenshot
Dr. Mario Screenshot
Dr. Mario Screenshot


Alternate Titles

  • "Virus" -- Working title
  • "ドクターマリオ" -- Japanese spelling
  • "닥터 마리오" -- Korean spelling (Hangul)

Part of the Following Groups

User Reviews

Play "Tetris" with Mario. Michael B (356) 4.75 Stars4.75 Stars4.75 Stars4.75 Stars4.75 Stars
Everybody (especially Tetris fans) will find themselves addicted to this game in minutes. pocketgamer2000 (22) 3.5 Stars3.5 Stars3.5 Stars3.5 Stars3.5 Stars

Critic Reviews

VideoGame Jul, 1991 5 Stars5 Stars5 Stars5 Stars5 Stars 100
Consoles Plus Sep, 1991 95 out of 100 95
Mean Machines Feb, 1991 87 out of 100 87
Video Games Jun, 1991 83 out of 100 83
Power Play Oct, 1990 83 out of 100 83
Megablast 1992 82 out of 100 82
Nintendojo Jul 03, 2003 8.2 out of 10 82
Raze Dec, 1990 81 out of 100 81
Total!! UK Magazine Jan, 1992 64 out of 100 64
Electronic Gaming Monthly (EGM) Nov, 1990 23 out of 40 58


There are currently no topics for this game.


1001 Video Games

Dr. Mario appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.


  • Game Informer
    • August 2001 (Issue #100) - #76 in the "Top 100 Games of All Time" poll

Related Web Sites

Kartanym (12721) added Dr. Mario (Game Boy) on Apr 03, 2002
Other platforms contributed by Michael Cassidy (21142), Kam1Kaz3NL77 (365440), Kartanym (12721) and gamewarrior (5048)