Insecticide is a handheld take on the PC version. In the future, Insects have become the dominant species on Earth and has replaced human beings. The player takes control of two insects by the name of Detective Chrys Liszt and partner Roachy Caruthers as they investigate a murder at the Nectarola Soft Drink Company.
There are many elements to the game, having the player interrogate suspects using good cop/bad cop techniques and interview witnesses in a story-based style. Players can also explore environments for clues, track suspect bugs and attack enemies with gameplay for this utilizing the stylus for aiming and the D-pad to move the main character and the L&R shoulder buttons to fire the weapon of choice.