Lizzie McGuire 2: Lizzie Diaries is largely a 2D side-scrolling platformer based on the Disney American comedy television series that ran between 2001 and 2004. Lizzie needs to complete levels avoiding obstacles and enemies. The latter can also be taken out by jumping on top of them. Lizzie has a limited amount of health, but when dead a level does not need to be restarted completely and the number of lives is infinite. The main goal is to reach the end of the level but optionally a certain number of diary collectibles can be picked up. In one level she needs to stay ahead of cheerleaders that chase her through the entire level.
Next to the regular platforming other levels contain several activities and mini-games such as playing games of beach volleyball, badminton, surviving a food fight, completing a waterski course, mimicking a dancing routine, dressing up Lizzie with a correct outfit, a time management game as a waitress and so on.