This release of Mercenaries 2: World in Flames differs from the other versions in several significant aspects. As opposed to the other releases, it uses the graphics engine from its predecessor Mercenaries: Playground of Destruction. Although the background story and basic gameplay remain the same, this version features about forty exclusive side-missions, has no co-operative play and takes place on a much smaller map.
Mercenaries 2 has been denounced by the Venezuelan president, Hugo Chávez, claiming the game is an effort by the United States government to drum up public support for a real-life invasion of Venezuela. Pandemic has been known to make training aids for the U.S. Army, but has stated that the game is nothing but pure entertainment only and has not been approached by the U.S. government to make this game.