Monsters vs. Aliens follows the storyline of the animated movie, giving players the chance to play each of the five monsters while taking on the evil robot and clone invaders of the plotting alien, Gallaxhar.
Each of the heroes has its own unique gameplay. B.O.B. explores puzzle-like platforming levels; Missing Link battles foes and obstacles in sidescrolling action levels; Ginormica skates through the streets of San Francisco and Modesto; Dr. Cockroach solves brainy minigames; finally, Insectosaurus fights off the alien menace in isometric, city stomping, levels. Along the way, the monsters find radioactive collectibles, unlock new features, and save the entire planet.