MouseCraft is a Lemmings-like puzzle game where you have to get at least one of three mice from the start to the target platform. The mice themselves will just move into one direction until they reach an obstacle, however they are able to climb over edges which are one block high. To modify the level you have a limited set of blocks resembling the well known Tetris blocks which can be placed before releasing the mice or during gameplay. The game may also be paused to place additional blocks or think about the next move.
The game's experiments are conducted by Dr. Schrödinger, a cat scientist. To finance his experiments (i.e. reaching the later levels) the mice will have to collect crystals (called Anima Shards) spread around the levels. When progressing you will get additional block types like Jelly Bricks (making it possible for your mice to fall more than 3 blocks without dying) or crumbling bricks (which will dissolve after 2 mice walked over them). Once set most blocks cannot be moved any more, but may be erased by collecting bombs in the level. Blocks will fall down if they aren't held any more, which can also be used to block or kill robotic enemy mice called 'Ratoids'.
The game features 80 levels in four different laboratories as well as a level editor to create own levels.