In Murakumo: Renegade Mech Pursuit, the player takes control of a mech pilot in control of the Murakumo, a mech in an elite unit designed to chase down a rebel mech army out to destroy the city of Oliver Port. The main goal of the game is to transverse the city in pursuit of a main rebel mech, destroying smaller enemies along the way and dodging varying obstacles. There are five different prototypes to choose from that carry weapons such as bazookas, sniper cannons and plasma swords.
There are 20 main missions to compete in, 10 more exclusive ones in the expert difficulty mode. Along with the story mode there is also a trial mode where the player can take on 10 different mech bosses solely for high rankings and a free mission mode where the player can redo previous missions in order to beat their previous records.