In New Orleans, Nancy Drew and her friend, Bess Marvin, are vacationing. There, the owner of a mystical and potentially powerful crystal skull, Bruno Bolet, is found dead, but the artifact is missing. Fearing the worst, Bruno's great-nephew, Henry, pleads with the sleuthful duo to find the skull and discover the circumstances which resulted in his uncle's death.
Roll up your sleeves, put on your thinking cap and investigate the case by exploring the Bolet manor and grounds (including its spooky cemetery) as well as the French Quarter and other parts of New Orleans. Talk to Bruno's friends and associates, who all have secrets to hide. Find hidden clues and evidence in inventory objects and reading materials. Solve adventure-type puzzles. Switch roles during the game by playing as Nancy and Bess.
The game is played completely by mouse with the keyboard used only while saving games. Features include several difficulty settings which directly affect how much help is given within the game, improved graphics, non-linear puzzle-solving, and weather and shadow effects.