NBA Live 10 is a simulation of the basketball sport. As usual the player controls the athletes himself and tries to perform typical basketball maneuvers with his gamepad. He can choose between playing a whole season, play-offs or the FIBA World Championship. In the Dynasty Mode the player takes the role of the executive of a basketball team which means he has to grapple with managerial tasks like transfers or training.
The most important feature of NBA Live 10 is the so-called "Dynamic DNA" which synchronizes the in-game statistics over the internet with the current data from the real league. In comparison to NBA Live 09 most new features are changes to the core game mechanics; especially the defense. Attempts to score now use just one button in combination with the analog sticks.