1001 Video GamesProfessor Layton and the Diabolical Box appears in the book 1001 Video Games You Must Play Before You Die by General Editor Tony Mott.
- 1UP's Readers' and Editors' Choice Awards
- 2009 - Best DS Game (Editors' Choice)
- 2009 - Best Puzzle Game (Editors' Choice)
- 2009 - Best Graphic Adventure (Readers' Choice)
- Cheat Code Central's Cody Awards.
- 2009 - Best Puzzle/Brain Game
- Game Informer's Awards
- 2009 - Best Puzzle Game
- GameTrailers' Game of the Year Awards
- 2009 - Best Puzzle/Parlor Game
- IGN Game of the Year Editors' Awards
- 2009 - Best DS Puzzle Game
- 2009 - Overall Best Puzzle Game
- Yahoo's Game Awards
- 2009 - Best Puzzle Game of the Year