After the Middle East, South America, the United States, and the former U.S.S.R, this fifth installment of the Strike takes the action to the heart of Asia, following the trail of Colonel LeMonde, who has terrorized South East Asia. LeMonde is armed with one prototype nuclear missile warhead, modified to catalyze a chain reaction that can completely destroy the ozone layer and thus irradiate the Earth. The hunt for LeMonde will take the player from Indocine (intended to suggest Indochina, the mainland of South East Asia), to the South China Sea to combat Napoleon Hwong, then to the heart of North Korea to uncover the nuclear schemes of Kym Zung-Lee (intended to suggest Kim Jong Il), and finally to Siberia for a final battle.
With the aid of fellow operatives, the player pilots the Super Apache, a fictional helicopter variant that is armed with Hellfire and Sidewinder missiles as well as Hydra cannons. Various other vehicles are also available during the course of the game, including tanks and jet fighters.
The ending of the game features an ad for a "coming soon" sequel, titled Future Strike. That game was already in development, but the project was scrapped and Future Strike became Future Cop: L.A.P.D.
The first trailer for Nuclear Strike featured a brief portion of heavy metal band Testament's Electric Crown.
When the game first launched, EA put out a TV ad blitz, featuring a crew at night taking a spray paint can and painting out the markings on a AH-1-type attack helicopter. Another TV ad dramatically depicted a nuclear explosion eviscerating a city in great detail, with some influence taken from Terminator 2: Judgment Day.