Over the Hedge: Hammy Goes Nuts! is a single-player top-down view touch screen game. The animals meet a new friend Boris the Beaver who needs a lot of help building his dam which little does everyone know, will flood all of Rancho Camelot Estates. The little creatures set video cameras everywhere to see where Dwayne is at all times and trigger gags to distract him.
The player has the ability to control several different players on any given level. The player needs to bribe these characters with various items to do their bidding. They must avoid hazards while raiding suburbia for various items to create gags. The gags will be used in the "D-TV" (Dwayne TV) mode where the player will see Dwayne the Exterminator on TV. Once the player sees him they can trigger a gag that causes something funny to happen to Dwayne distracting him.