Papo & Yo is a unique puzzle-platforming game with a very personal story. In the game, the player character is the young boy Quico. His best friend is a huge and dangerous monster which has a terrible addiction to poisonous frogs. Frogs, that turn the monster violent and angry, whenever it consumes one. Joining Quico on his journey are Lula, his trusty doll, and the mysterious girl Alejandra.
The game is set in a very surreal world modelled after the suburbs of an ordinary South American city. The city morphs and shifts, sometimes on the player's command, to create or solve puzzles and make new areas accessible. The player character is unarmed and all interaction is done by manipulating the environment through levers, simple (but surreal) contraptions or by guiding the monster with fruits.
The game is an allegory for the teenage years of its creator and what he had to endure under his alcoholic father. Many of the themes in the game are standing for real life struggles and occasionally the veil shifts and the game uses accurate graphics to depict what had happened instead of the surreal visuals it usually uses.