The story begins in 1997. It's the dead of night in the city of Los Angeles, and there has been a mass murder at a general hospital on the outskirts of downtown. The perpetrator is the director of the hospital, Richter Harris. He has shut himself up in the hospital and taken a number of patients as hostages, leaving the police helpless and unable to move in. Richter's only daughter, Laura Harris, after hearing the situation, rushes to Los Angeles from San Francisco, and drives alone to the tragic scene at the hospital ground. Upon entering the hospital Laura finds herself transported to an old mansion, while the disembodied voice of her father pleads with her to leave. Nevertheless she must press forward to save her father and herself.
D is a puzzle game requiring Laura to solve esoteric inventory puzzles on a very strict time limit. Each of the game's four discs must be completed in about thirty minutes each, and saving is not an option. The time is kept track of using Laura's pocket watch. The pocket watch can also be used to supply hints for puzzles, but after three uses the glass will shatter and it will stop working. The game also has multiple endings.
The game contains a lot of violence and even cannibalism, which was a taboo at that time. Main director Kenji Eno of Warp Inc. used a trick to get the game approved. He submitted the master to 3DO with a clean version of the game. When it was approved, he took it to the US to have it manufactured, but switched the discs and had it released as he had intended.
Together with Acclaim, 100,000 orders were ordered from Sony for the PlayStation version. Sony however gave priority to other titles and told Warp Inc. only 40,000 copies would be made, which became a mere 28,000 units in the end. Main director Kenji Eno took revenge later at a Sony event where he gathered the members of press to announce that the company would be making games for the SEGA Saturn. Sony, hosting the event, was of course not pleased.