In this pokemon themed game, you must move and match blocks to clear the board before the blocks fill up the screen. It's a tetris like game, with pokemon twist. There are many different ways to play the game, including a challenge with gym leaders, puzzle practice, and a straight, play til you lose, marathon mode. This game can also be linked with other gameboys for challenge of real people.
If you load Pokemon Puzzle Challenge on the original Game Boy, and then press the A and B buttons 24 times each (A first, B second), you can access what appears to be an unfinished prototype of "Panel De Pon GB". It also seems like there were initially plans to keep the fairies intact in the European and American releases of "Panel De Pon GB", as opposed to replacing them in a similar vein to the SNES game.