Lora is a North-American woman of Russian origin whose marriage is in trouble. In an attempt to save their relationship, she decides to travel to St. Petersburg to spend some time together with her distant husband Mark, and find more about her family's history. After leaving their young son with Mark's parents, she suddenly starts to be assaulted with hallucinations and visions of the legendary mystic Rasputin. She arrives early at home to pack and prepare for the trip, and ends up eavesdropping by accident Mark and a strange woman on a intimate moment. Shocked and hurt, she embarks without him in a plane to Europe, where she hopes to find details about her past and the haunting ghost of Rasputin.
Rasputin's Curse is a hidden object game with elements from the adventure genre. Most of the time, the objective is to find and click on all the items listed at the right side of the screen, on locations filled with assorted objects scattered around the scenery. Some of the objects are stored on the inventory tray at the bottom, to be dragged and dropped on specific portions of the scene to complete a task or perform an action. For example, a key can be used on a lock to open a door or other compartment. In some places, the list displays the objects' silhouettes instead of their names. The hint button shows the position of one of the required items, but takes some time to recharge after use.
There are some mini-games that take place on separate screens, where the player has to discover the correct sequence of keys on locks by trial-and-error to open a safe, reassemble shredded pictures, manuscripts and notes, reconstruct an answering machine, collect falling sheets of paper, find the differences between two similar images and complete other challenges.