Run Sackboy! Run! is an endless runner platform game featuring the lead character from the LittleBigPlanet series. When starting out we find Sackboy being chased by the Negativitron and it's up to the player to help him out so that he is not caught. Like in other games of its kind all forward movement is automatic and all the player has to do is tap the screen at the right time to make Sackboy jump. Jumping is needed to avoid obstacles and enemies as well as collecting bubbles and other items that can be found. Colliding with an obstacle like spikes or an enemy and the game ends, however enemies are knocked out if jumped onto. What also needs to be avoided is the pink goo which slows down Sackboy and allows the Negativitron to catch up. To escape it the player has to swipe across the screen to gain speed.
The game is free-to-play and the bubbles are the main currency used in the game. These are collected in the game but can also be acquired with real money. In the game's shop bubbles can be used to acquire costumes and power-up upgrades as well as lucky chests with random content. Like in many other free-to-play games there are boosts that can be activated before a game and also these cost bubbles. Another way to spend bubbles is to skip mission challenges. Missions are done by clearing specific objectives and by doing them the player can level up. By levelling up the player's score multiplier increases. Another object that the player can collect in the game as well as acquire with real money are the save-me-hearts. These can be used at the game over screen to revive Sackboy and allows the player to continue playing without losing his score.
Some power-ups can be found around the stages and they are automatically activated when picked up. This includes a magnet that allows Sackboy to collect bubbles at a a greater range and the jetpack which allows him to fly. They are active for a limited amount of time but by spending bubbles on upgrades this time can be extended. Other objects that can be collected are stickers. Once all stickers of a certain theme have been collected the player is awarded with a special prize. There are also some stickers that unlock content in other LittleBigPlanet games.