Cowabunga! Take control of your favourite turtle ninjas as you play through the events of the 2007 CGI movie. The turtles have grown apart, and Raphael has taken to crime fighting solo under the guise of the Nightwatcher. The Foot Clan are turning up in the streets again, and a mysterious man known as Winters seems to be involved with them. Only the Ninja Turtles can clean up the streets!
The Game Boy Advance version of TMNT can be best described as similar to the NES game River City Ransom. Players take control of either a specific turtle or the turtle of their choice (depending on the mission), and fight through waves of enemies in a sidescrolling beat-em-up style. Enemies will drop the usual health pickups, but also drop money and weaponry. Money can be used to purchase weapons or upgrades between missions, while weapons can be used as a more powerful tool to defeat your foes (however, these weapons have a limited use). After the completion of a mission, experience is earned, and after a certain amount of experience is gained, you can level up the turtles to improve their fighting statistics.
Each turtle has their own specific weapon: Leonardo with his dual Katana, Michelangelo with his Nunchucks, Donatello with his Bo Staff and Raphael with his two Sai. These weapons are used in their standard attacks. A basic attack is performed with the B Button, but you can perform different attacks with B and other buttons such as the directions of the Control Pad and the A Button. Uppercuts, Sweep Kicks, Jump Kicks and more can be performed, and you can even juggle enemies in the air to get more hits in and increase your score.