Welcome House 2: Keaton & His Uncle is a sequel to the Welcome House adventure game. The game starts on the 4th of July with Keaton sleeping in bed when his prankster uncle Parkinson gives him a bombing wake-up call. Confused and angry, Keaton goes through all the traps he had set for him to find his uncle, give him a piece of his mind and leave the mansion for good.
Players once again navigate Keaton through the mansion. The gameplay can be described as playing Resident Evil but without the monsters. The slapstick humor is still intact with more explosions, trapdoors, shower scenes and a laugh track when Keaton gets into any of these traps. The game also adds voice acting for the dialogues. None of the traps are lethal so players can enjoy seeing how Keaton gets squished, smashed, trips and falls and can't progress to a new area without pulling the necessary levers. Players will still need to locate keys and other items and use them to progress through the game.