John Cooper's brother, Marshal Ross Cooper, was brutally murdered by a criminal known as "Angel Face". Swearing revenge, John sets out to uncover the killer's identity and avenge his brother's death. To reach Angel Face, John will need to reassemble his gang of bounty hunters, including old friends like Doc McCoy and Kate O'Hara, as well as recruit new members into the group.
Desperados 2: Cooper's Revenge is the sequel to Desperados: Wanted Dead or Alive. Once again players control John Cooper and his gang. Though it's possible to play the game in an isometric view much like the previous game, Desperados 2 is rendered fully in realtime 3D, allowing the player to zoom and rotate the camera in many ways. The camera can even be switched to a third person view and follow individual characters around. This increased functionality becomes especially useful when moving around inside a building or engaging enemies in gunplay.
The game is divided into several challenging missions, that have to be solved by using the characters' different abilities to overcome large numbers of enemies. Some examples include the sensual Kate seducing enemies with her charms, while Sam blows things up with his dynamite and Doc heals his comrades.
According to Andreas Speer, the game had a troubled development: Publisher Atari missed six months worth of payment which forced Spellbound Entertainment AG to lay off staff. Later the money was made available thanks to external funds, but the project timeline remained unchanged.