Having fought in the Middle East, South America, within the United States, and in the former U.S.S.R, your path has now lead you to the heart of Asia. You follow the trail of Colonel LeMonde, who has terrorized South East Asia. LeMonde is armed with one prototype nuclear missile warhead, modified to catalyze a chain reaction that can completely destroy the ozone layer and thus irradiate the Earth. Your hunt starts in Indocine (intended to suggest Indochina, the mainland of SE Asia), then to the South China Sea to combat Napoleon Hwong, then to the heart of North Korea to uncovering the nuclear schemes of Kym Zung-Lee (intended to suggest Kim Jong Il), and then to Siberia for a final battle.
With the aid of fellow operatives, you strap up in the good old Super Apache, -- a fictional helicopter variant that is armed with Hellfire and Sidewinder missiles and with Hydra cannons. There are also numerous other vehicles that you come to be able to use, including tanks and jet fighters. Do all you can to defeat LeMonde and remove him from Southeast Asia!
The ending of the game features an ad for a "coming soon" sequel, titled Future Strike. That game was already in development, but the project was scrapped and Future Strike became Future Cop: L.A.P.D.
The first trailer for Nuclear Strike featured a brief portion of heavy metal band Testament's Electric Crown.
When the game first launched, EA put out a TV ad blitz, featuring a crew at night taking a spray paint can and painting out the markings on a AH-1-type attack helicopter. Another TV ad dramatically depicted a nuclear explosion eviscerating a city in great detail, with some influence taken from Terminator 2: Judgment Day.