Take No Prisoners is a top-down 3D shooter that takes place in a post-apocalyptic environment. The player controls Slade, a mercenary recruited by The Man to retrieve a special crystal from a mysterious dome, deep in the irradiated hell-hole of San Antonio, Texas. As the story progresses, the player collects data files from computers and dead enemies, System Shock-style, and places them in a Personal Data Device.
There are over twenty areas in the game, which can be explored on foot or using ATVs, hovercrafts, or sewer boats, in a largely non-linear fashion. The enemies vary from obsessed cultists wielding laser swords to mechanical warriors who use shoulder-mounted lasers.