Zombie Infection 2 is a horror-themed action game played from a bird's view perspective that has game mechanics similar to its predecessor. Taking place a year after the events of the first game, it sees Anderson, the hero of the original zombie outbreak, go to South America with a reporter (Keysha) only to see the undead rise again. Both characters are playable as is a native called Jeremi. The setting and some of the locations are similar to the series' smartphone entry but it has an original story and different characters.
The game plays the same as the original Zombie Infection but it's more action oriented and has less emphasis on survival horror elements. When encountering a threat, a vertically moving crosshair appears atop of the enemy and the player has to time the shot for maximum damage (ideally by hitting the head). Anderson and Keysha have access to firearms such as handguns and shotguns while Jeremi uses a spear for melee combat and a bola for ranged attacks. In addition to the action, there are some puzzle elements. Items are collected and are sometimes combined to create new items that are needed to progress past obstacles.