Zombie Infection is a mobile survival horror game where a soldier and a reporter travels to South America to uncover unethical business practices only to end up in the middle of a zombie outbreak. It is based on the feature phone game with the same name but has original characters, settings and storyline. The game is similar to Resident Evil 4 with a behind view perspective that changes to a zoomed-in shoulder view when aiming. Weapons include a pistol and a shotgun and it's also possible to attack enemies in melee combat. A final blow can be delivered by triggering an instant-kill attack once an enemy has been knocked down or is low on health. The player should aim at the head for maximum damage or at limbs which can be shot off. The game also has some occasional brief quick time events.
There are twelve levels in the story mode each which involves moving from point to point, killing zombies (and some animals such as lions and alligators) before reaching a boss fight at the end. After starting out in a favela the player will have to make it through a zoo, mines, docks and a boat. Once the story mode has been completed, a survival mode is unlocked.