In-game, your goal is to build up music by blasting note gems along each track of a song, which represents a different instrument. Successfully clearing and switching between tracks without missing gems allows the player to score more points. Various powerups allow the player to clear a track, slow down the music, add a freestyle solo, and double their score.
Amplitude consists of a 15-level campaign mode, which details the game's science-fiction storyline within the lyrics of each song. There are also 15 bonus songs, which include both original compositions as well as selections from indie game composers.
Amplitude also includes a competitive multiplayer mode, where multiple players compete to score the most points on a song.