Call of Juarez: Gunslinger is the fourth main game in the shooter series and a return to the Old West setting of the second game Call of Juarez: Bound in Blood. The player controls the bounty hunter Silas Greaves and the game is organized around three game modes: Story, Arcade and Duel. Arcade consists of travelling through a location defeating waves of enemies and gaining a high score by keeping the combo going, while Duel is a series of gunslinger duels.
The protagonist Silas Greaves also narrates the story in the Story mode and the player completes a series of missions through linear levels. The game is set in 1910 when Greaves enters a saloon in Abilene, Kansas and tells his bounty hunting tales. These cut-scenes are presented as a series of drawn, still images with voice-overs. The gameplay sequences are then played as flashbacks. Greaves however proves to be an unreliable narrator and when he gets called out during certain moments, these affect the game environment immediately, removing or introducing new elements. The player can also hunt down Nuggets of Truth, which recount the historical truths behind his tales.
The gameplay consists of completing objectives and shooting down enemies. He has access to different guns and experience points can be used to expand his skills and use dual pistols, shotguns and rifles. Skills are divided over three categories: Gunslinger (dual wielding), Ranger (long distance) and Trapper (close quarters) with upgrades such as faster aiming, faster reloading and more. Gameplay includes the bullet time ability (Concentration), gunslinger duels that require quick reflexes, and dodging bullets through quick time events. Lethal shots can only be avoided when the Sense of Death meter is fully charged. There is complete freedom of movement and Greaves often has to seek cover behind rocks. Precise aiming through headshots is rewarded with more points.