Chiral is a puzzle game where the player has to create stable molecules by connecting atoms. Atoms drop down into a vial one at a time and by clicking on the playfield the atom on the bottom will be placed where the mouse is. Each atom has a dot pattern that indicates how many other atoms it needs to be connected to. Atoms placed together will automatically bond. Once all atoms in the molecule have been fully bonded it becomes stable and is removed from the screen. In each level the objective is to complete a number of molecules with a minimum number of atoms in each. At the same time the vial is not allowed to overflow with atoms. When starting out the player has a limited amount of schzapps that clears out the vial if it overflows but after they have been used up overflowing leads to game over.
There are also some special atoms such as heavy atoms which can't be switched once placed and the speed atom that causes the atoms to fall into the vial at a higher pace. There are also radioactive atoms that clear out all atoms in the bond chain and secret atoms whose number of required bonds are unknown. Sometimes walls will appear on the playfield and these can not be bonded through meaning that chains have to be built around them.